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Best pain relievers - April 2025

Last Updated - April 26, 2025

1
Best Choice

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Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Aleve

Aleve Back & Muscle Pain Relief Naproxen Sodium Tablets, Pain Reliever & Fever Reducer, Medicine for Body , 250 Count

Aleve

$24.99

More Details
Main highlights
- Up to 12-Hours of Uninterrupted Pain Relief: Aleve Back & Muscle Pain Relief Tablets provide long-lasting back pain and muscle pain relief
- Targeted Pain Relief: Every tablet is made with 220 mg of naproxen sodium to help you take on muscle pain and provide back pain relief
- Fever Reducer: Temporarily reduces fever for adults and children aged 12 and up
- Effective Pain Reliever: In a study, proven as effective and longer lasting than a common Rx pain reliever. Ask a doctor if Aleve is right for you
- Comes in small, easy-to-swallow tablets; use as directed
$24.99
2
Best Value
25% Off

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Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

VOLTAREN
25% Off

Voltaren Arthritis Pain Gel for Powerful Topical Arthritis Pain Relief with Diclofenac - NEW Easy Open Cap - 100 g x 2

VOLTAREN

$24.27

$32.49
(25% Off)

More Details
Main highlights
- Voltaren Arthritis Pain Gel comes in a tube with flip cap and includes dosing card for proper dosage
- Voltaren Arthritis Pain Gel Penetrates Deep to attack arthritis pain directly at the source of inflammation, treating arthritis pain
- Two 3.5 oz/100 g tubes of Voltaren Arthritis Pain Gel for Powerful Topical Arthritis Pain Relief- Easy flip cap that can be opened with your palm, fingers, or even with just one hand; packaging may vary
- Significant Arthritis Pain Relief, within seven days of continuous use and long-lasting relief when applied four times a day; apply on up to two joints at the same time for hand pain, wrist pain, elbow pain, ankle pain, foot pain or knee pain relief
- Paraben and Dye-Free, Voltaren diclofenac gel is a non-greasy and clean scented gel
- Number 1 Doctor Recommended topical pain relief brand
- HSA and FSA eligible product
- Clinically Proven to relieve arthritis pain, improve mobility and reduce stiffness, aches and pains to provide prescription strength arthritis pain relief
- An Alternative to Pills, Voltaren is a nonsteroidal anti-inflammatory gel that combines the benefits of an arthritis cream and gel for arthritis pain management*
$24.27
$32.49 (25% Off)
3
24% Off

✖
Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Tylenol
24% Off

Tylenol Extra Strength Acetaminophen Rapid Release Gels, Extra Strength Pain Reliever & Fever Reducer, Gelcaps with Laser-Drilled Holes, 500 mg Acetaminophen, 100 ct

Tylenol

$12.47

$16.59
(24% Off)

More Details
Main highlights
- With 500 mg of acetaminophen per gelcap, this extra strength oral pain reliever is fast-acting and can be used by adults and children who are 12 years and older
- Use as a fever reducer and to relieve minor aches and pains including headache, backache, toothache, menstrual and premenstrual cramps, minor pain of arthritis, joint and muscle pain, and pain caused by the common cold and flu
- Experience relief of minor aches and pains with Tylenol, the #1 doctor recommended brand for pain relief and fever reduction
- Each pain reliever gelcap features laser-drilled holes to quickly release pain medicine and contains 500 mg of acetaminophen for fast, effective extra strength pain relief that works at the speed of life, while being gentle on the stomach
- 100-count Tylenol Extra Strength Rapid Release Gels pain relief medicine with acetaminophen work fast to temporarily relieve minor aches and pains, headaches, and help reduce fever
$12.47
$16.59 (24% Off)
4

✖
Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Tylenol

Tylenol Extra Strength 500 mg Acetaminophen Caplets, Pain Reliever & Fever Reducer, Acetaminophen for Minor Arthritis Pain, Headache, Backache & Toothache, Value Size, 100 Ct

Tylenol

$10.97

$12.04
(8% Off)

More Details
Main highlights
- Use 500 mg acetaminophen caplets as a fever reducer and to help provide relief of common pain symptoms including headache, backache, toothache, menstrual cramps, and pain caused by the common cold
- This extra strength acetaminophen pain reliever can be used by adults and children who are 12 years and older. To use, take two acetaminophen caplets every six hours while symptoms last and do not take more than six caplets in 24 hours
- From the #1 doctor recommended brand for pain relief and fever reduction, experience relief from minor aches and pains with Tylenol Extra Strength Caplets with 500 mg Acetaminophen
- Each extra strength Tylenol pain relief caplet contains 500 mg of acetaminophen for strong and effective pain relief, and has an excellent safety profile when used as directed
- 100-count value size bottle of Tylenol Extra Strength Caplets with 500 mg of acetaminophen, a known pain reliever and fever reducer, to provide temporary relief of minor aches and pains and reduce fever
$10.97
$12.04 (8% Off)
5
10% Off

✖
Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Amazon Basic Care
10% Off

Amazon Basic Care Naproxen Sodium Tablets 220 mg, Pain Reliever/Fever Reducer (NSAID), Muscular Aches, Backache, Headache, Toothache, Minor Arthritis Pain Relief & More, 300 Count (Packaging may vary)

Amazon Basic Care

$13.47

$14.99
(10% Off)

More Details
Main highlights
- STRENGTH TO LAST 12 HOURS: Pain reliever and fever reduction for up to 12 hours so you can get through the day
- CAPSULE-SHAPED TABLETS: This 12 hour pain reliever and fever reducer comes in a capsule-shaped tablet; this product is gluten free
- ALL DAY RELIEF: Amazon Basic Care Naproxen Sodium Tablets 220 mg is a pain reliever and fever reducer for adults and children age 12 years and over
- ACTIVE INGREDIENT: This pain reliever and fever reducer contains naproxen sodium 220 mg, a nonsteroidal anti-inflammatory drug (NSAID); compare to the active ingredient in Aleve Caplets
- ACHES AND PAINS: Temporarily relieves minor aches and pains due to minor pain of arthritis, muscular aches, backache, menstrual cramps, headache, toothache and the common cold; also temporarily reduces fever
$13.47
$14.99 (10% Off)

Best pain relievers - April 2025

Aleve Back & Muscle Pain Relief Naproxen Sodium Tablets, Pain Reliever & Fever Reducer, Medicine for Body , 250 Count

Voltaren Arthritis Pain Gel for Powerful Topical Arthritis Pain Relief with Diclofenac - NEW Easy Open Cap - 100 g x 2

Tylenol Extra Strength Acetaminophen Rapid Release Gels, Extra Strength Pain Reliever & Fever Reducer, Gelcaps with Laser-Drilled Holes, 500 mg Acetaminophen, 100 ct

Tylenol Extra Strength 500 mg Acetaminophen Caplets, Pain Reliever & Fever Reducer, Acetaminophen for Minor Arthritis Pain, Headache, Backache & Toothache, Value Size, 100 Ct

Amazon Basic Care Naproxen Sodium Tablets 220 mg, Pain Reliever/Fever Reducer (NSAID), Muscular Aches, Backache, Headache, Toothache, Minor Arthritis Pain Relief & More, 300 Count (Packaging may vary)

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Amazon Basic Care Acetaminophen Extended-Release Tablets, 650 mg, Arthritis Pain, 400 Count

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Amazon Basic Care Ibuprofen Tablets 200 mg, Pain Reliever/Fever Reducer, Body Aches, Headache, Arthritis Pain Relief and More, 500 Count (Packaging may vary)

Amazon Basic Care Extra Strength Pain Relief, Acetaminophen Caplets, 500 mg, Pain Reliever/Fever Reducer, 500 Count (Packaging may vary)

GoodSense Extra Strength Pain Relief, Acetaminophen Caplets, 500 mg, 500 Count

Amazon Basic Care Extra Strength Pain Relief, Acetaminophen Caplets, 500 mg, Pain Reliever/Fever Reducer, 100 Count (Packaging may vary)

Aleve Pain Relief Naproxen Sodium Caplets ‐ 50 Count

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