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Best acetaminophens - September 2025

Last Updated - September 10, 2025

1
Best Choice

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Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Generic

Acetaminophen 500mg, Extra Strength Acetaminophen gelcaps, Rapid Release, 400 Gelcaps

Generic

$29.99

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- Acetaminophen 500mg, Extra Strength Rapid Release, 400 Gelcaps
$29.99
2

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Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

TIME-CAP LABS, INC.

TIME-CAP LABS, INC. Timely Acetaminophen 650 MG - 400 Caplets - Extended Release - Joint Pain Relief, Pain Reliever & Arthritis Pain Relief

TIME-CAP LABS, INC.

$21.99

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Main highlights
- Relieve Minor Aches and Pains ... Toothache? Backache? Acetaminophen relieves minor aches and pains due to headache, backache, toothache, the common cold, minor pain of arthritis, muscular aches, and premenstrual and menstrual cramps.
- One in Every Medicine Cabinet ... Make sure every medicine cabinet and first-aid kit has these great pain relief tablets. 400 caplets are plenty enough to provide long-term relief for the family.
- Let That Fever Subside ... Dealing with a fever? Acetaminophen temporarily reduces fever, and relieves those aches and pains caused by minor pain of arthritis.
- Highest Quality ... These OTC medications & treatments provide the same efficacy as your usual branded extra strength acetaminophen.
- An Easy Way to Be Pain-Free … Find prolonged relief in a bottle of this Arthritis Pain Relief Acetaminophen 650mg. Take as directed on the bottle.
$21.99
3

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Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Amazon Basic Care

Amazon Basic Care Acetaminophen Extended-Release Tablets, 650 mg, Arthritis Pain, 400 Count

Amazon Basic Care

$21.08

$22.22
(5% Off)

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Main highlights
- TEMPORARY PAIN RELIEF: This product may also be used to temporarily relieve other minor aches and pains due to: muscular aches, backache, premenstrual and menstrual cramps, the common cold, headache, toothache.
- PUSH & TURN CAP: The container has a child-resistant cap. This product is a pain reliever and fever reducer for adults. Under 18 years of age, ask a doctor.
- PURPOSE: Amazon Basic Care Acetaminophen Extended-Release Tablets, 650 mg is a pain reliever and fever reducer that can be used for the temporary relief of minor pain of arthritis.
- ASPIRIN FREE, GLUTEN FREE: Extended release caplets (capsule-shaped tablets) each provide 650 mg of acetaminophen, pain reliever and fever reducer, and contain no aspirin. Effective for minor arthritis pain. This product is gluten free.
- ACTIVE INGREDIENT: Amazon Basic Care Acetaminophen Extended-Release Tablets, 650 mg active ingredient is acetaminophen 650 mg,. Compare to the active ingredient in Tylenol 8HR Arthritis Pain.
$21.08
$22.22 (5% Off)
4
16% Off

✖
Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Amazon Basic Care
16% Off

Amazon Basic Care Rapid Release Acetaminophen Caplets 500 mg, Extra Strength Pain Reliever and Fever Reducer, 400 Count

Amazon Basic Care

$15.86

$18.89
(16% Off)

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Main highlights
- GLUTEN FREE: This pain reliever and fever reducer is free of gluten, aspirin and caffeine.
- FOR ADULTS: Amazon Basic Care Rapid Release Pain Relief, Acetaminophen Caplets 500 mg contain an extra strength pain reliever and fever reducer for adults and children ages 12 years and over
- EXTRA STRENGTH: These extra strength caplets are made for fast relief, with 500 mg of acetaminophen; package features a child-resistant cap
- EFFECTIVE: This product temporarily relieves minor aches and pains due to headache, muscular aches, backache, minor pain of arthritis, the common cold, toothache and premenstrual and menstrual cramps. Also temporarily reduces fever.
- ACTIVE INGREDIENT: Amazon Basic Care Rapid Release Acetaminophen 500 mg Caplets active ingredient is 500 mg of acetaminophen, a pain reliever and fever reducer. Compare to Tylenol Extra Strength Rapid Release Gels active ingredient.
$15.86
$18.89 (16% Off)
5
Best Value
24% Off

✖
Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Tylenol
24% Off

Tylenol Extra Strength Acetaminophen Rapid Release Gels, Extra Strength Pain Reliever & Fever Reducer, Gelcaps with Laser-Drilled Holes, 500 mg Acetaminophen, 100 ct

Tylenol

$12.47

$16.59
(24% Off)

More Details
Main highlights
- With 500 mg of acetaminophen per gelcap, this extra strength oral pain reliever is fast-acting and can be used by adults and children who are 12 years and older
- Use as a fever reducer and to relieve minor aches and pains including headache, backache, toothache, menstrual and premenstrual cramps, minor pain of arthritis, joint and muscle pain, and pain caused by the common cold and flu
- Experience relief of minor aches and pains with Tylenol, the #1 doctor recommended brand for pain relief and fever reduction
- Each pain reliever gelcap features laser-drilled holes to quickly release pain medicine and contains 500 mg of acetaminophen for fast, effective extra strength pain relief that works at the speed of life, while being gentle on the stomach
- 100-count Tylenol Extra Strength Rapid Release Gels pain relief medicine with acetaminophen work fast to temporarily relieve minor aches and pains, headaches, and help reduce fever
$12.47
$16.59 (24% Off)

Best acetaminophens - September 2025

Acetaminophen 500mg, Extra Strength Acetaminophen gelcaps, Rapid Release, 400 Gelcaps

TIME-CAP LABS, INC. Timely Acetaminophen 650 MG - 400 Caplets - Extended Release - Joint Pain Relief, Pain Reliever & Arthritis Pain Relief

Amazon Basic Care Acetaminophen Extended-Release Tablets, 650 mg, Arthritis Pain, 400 Count

Amazon Basic Care Rapid Release Acetaminophen Caplets 500 mg, Extra Strength Pain Reliever and Fever Reducer, 400 Count

Tylenol Extra Strength Acetaminophen Rapid Release Gels, Extra Strength Pain Reliever & Fever Reducer, Gelcaps with Laser-Drilled Holes, 500 mg Acetaminophen, 100 ct

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GoodSense Extra Strength Acetaminophen Caplets 500 mg, Pain Reliever and Fever Reducer, Easy Open Cap, 100 Count

Acetaminophen Generic 500 mg Extra Strength - 600 Caplets

Amazon Basic Care Extra Strength Pain Relief, Acetaminophen Caplets, 500 mg, Pain Reliever/Fever Reducer, 500 Count (Packaging may vary)

Amazon Basic Care Extra Strength Pain Relief, Acetaminophen Caplets, 500 mg, Pain Reliever/Fever Reducer, 100 Count (Packaging may vary)

Amazon Basic Care Acetaminophen Extended-Release Tablets, 650 mg, 100 Count (Packaging may vary)

Tylenol Regular Strength Tablets with 325 mg of Acetaminophen, Fever Reducer & Pain Reliever for Headache, Backache, Muscle Aches, Joint Pain & Menstrual Cramps, 100 ct

Globe Extra Strength Acetaminophen Tablets 500 mg, Pain Reliever and Fever Reducer, Gentle on Stomach, for Arthritis Pain, Backache Pain and More, 50 Packets of 2 Tablets Each, 100 Count

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